Pre-implantation screening
Indications: Genetic diseases of the parents
When both parents are carriers of a recessive disease
Detection of chromosomal anomalies
Women over 40 years of age
Couples with a history of multiple failed IVF attempts
When one parent is a carrier of a dominant or sex-linked disease
Couples with offspring or pregnancies of embryos with chromosomal disorders
Couples with a history of miscarriages
Giving birth to HLA-compatible offspring
Pre-implantation genetic testing is used for the identification
of single gene disorders in embryos, such as:
Single gene disorders
Thalassemia
Sex-linked diseases
Duchenne’s muscular dystrophy
Cystic fibrosis
Huntington’s chorea
Hemophilia
Sex-linked mental retardation
Obviously, PGT can only be performed in the context of IVF. The couple’s embryos are submitted to a biopsy and the cells retrieved from each embryo are submitted to genetic screening. Only normal embryos are implanted in the woman’s uterus.